MEDIATORS OF INFLAMMATION: AN INTRODUCTION
Author: Sanketh DS, MDS
Inflammation is fundamentally a protective response of the body against any offending agent or tissue damage. It involves responses of the vascular tissues, leukocytes, mast cells and macrophages which help in getting rid of the cause of tissue insult or injury. So, how is an inflammatory response triggered? Microbes, necrotic cells or tissue injury could trigger the release of certain soluble factors, from inflammatory cells, endothelial cells or from plasma. These soluble factors, called mediators of inflammation, initiate and amplify the inflammatory response and determine the consequent clinical and pathologic manifestations.
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