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Bone resorption process by osteoclasts

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Q&A: How do osteoclasts resorb bone?

Author: Sanketh DS, MDS

INTRODUCTION

Osteoclasts are large multinucleated giant cells having around 15-20 nuclei, whose function is to resorb bone. They play a very important role in bone remodelling and are characterised by the presence of an enzyme called tartrate resistant acid phosphatase (TRAP). Osteoclasts are haematopoietic in origin and are derived from the monocyte/macrophage lineage of cells.

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