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Dentinogenesis

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DENTINOGENESIS

Author: Sanketh DS, MDS

INTRODUCTION

Dentinogenesis is the process of formation of dentin. It starts off with the deposition of predentin which is an unmineralized organic matrix comprising majorly of collagen and a tiny fraction of non-collagenous proteins. This is followed by mineralisation of the organic matrix/proteins thus forming dentin. The organic matrix/proteins comprise mainly type I collagen with fractions of type III and type V collagen. Dentin phosphoprotein (DPP), dentin sialoprotein (DSP), dentin sialophosphoprotein(DSPP), osteonectin, osteopontin and Gla protein make up for non-collagenous proteins. Together they make up around 20% of dentin and along with water comprise 30% of dentin. The rest of the dentin is made of inorganic material composed of hydroxyapatite.

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