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Author: Sanketh DS, MDS


Dentinogenesis is the process of formation of dentin. It starts off with the deposition of predentin which is an unmineralized organic matrix comprising majorly of collagen and a tiny fraction of non-collagenous proteins. This is followed by mineralisation of the organic matrix/proteins thus forming dentin. The organic matrix/proteins comprise mainly type I collagen with fractions of type III and type V collagen. Dentin phosphoprotein (DPP), dentin sialoprotein (DSP), dentin sialophosphoprotein(DSPP), osteonectin, osteopontin and Gla protein make up for non-collagenous proteins. Together they make up around 20% of dentin and along with water comprise 30% of dentin. The rest of the dentin is made of inorganic material composed of hydroxyapatite.


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