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Fibrous dysplasia

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FIBROUS DYSPLASIA: CLINICAL, RADIOGRAPHIC FEATURES & TREATMENT

Author: Sanketh DS, MDS

INTRODUCTION

Fibrous dysplasia is a tumor like developmental condition, characterized by proliferation of abnormal cellular fibrous connective tissue with irregular trabecular bone replacing the normal medullary bone. This condition occurs due to a mutation in the GNAS (Guanine nucleotide-binding protein,α stimulating activity polypeptide) gene, encoding for the α subunit of G protein. Fibrous dysplasia affects/involves one bone (monostotic) or multiple bones(polyostotic), sometimes together with endocrine abnormalities and abnormal pigmentation.

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