FIBROUS DYSPLASIA: PATHOGENESIS &
Author: Sanketh DS, MDS
Fibrous dysplasia is a tumor like developmental condition, characterised by proliferation of abnormal cellular fibrous connective tissue with irregular trabecular bone replacing the normal medullary bone. This condition occurs due to a mutation in the GNAS (Guanine nucleotide-binding protein,α stimulating activity polypeptide) gene, encoding for the α subunit of G protein. Fibrous dysplasia affects/involves one bone (monostotic) or multiple bones (polyostotic), sometimes together with endocrine abnormalities and abnormal pigmentation.
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OTHER (HACKDENTISTRY) PRACTICE/STUDY RESOURCES