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Erythema multiforme



ERYTHEMA MULTIFORME: PATHOGENESIS, CLINICAL FEATURES, HISTOPATHOLOGY & TREATMENT

Author: Sanketh DS, MDS

INTRODUCTION

Erythema multiforme (EM) is an ulcerative, blistering inflammatory condition which affects either the skin or the mucous membranes, most often manifesting as a mucocutaneous lesion.  Depending on the severity of the condition and the extent of mucosal involvement, it can be classified as EM minor and major. Previously two other conditions called Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) (also called Lyell disease) were considered to be a part of the spectrum of EM, although on the more severe end of the disease. They involve wider areas of the muco-cutaneous region and can be life threatening.  However, these two conditions are now not considered to be part of the EM spectrum and are designated as distinct entities.

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