PERNICIOUS ANEMIA: VIT B12 ABSORPTION, PATHOGENESIS, CLINICAL FEATURES AND DIAGNOSIS
Author: Sanketh DS, MDS
Pernicious anemia is a type of megaloblastic anemia caused due to the lack of a substance called intrinsic factor, which leads to deficiency of Vitamin B12. Intrinsic factor is a glycoprotein produced by the parietal cells in the fundic region of the stomach that helps Vitamin B12 be absorbed by the body. Vitamin B12 along with folate is necessary for the synthesis of a protein called thymidine. Thymidine forms one of the building blocks of DNA. Deficiency of thymidine causes abnormalities in rapidly dividing cells of the body, especially red blood cells. Impaired DNA formation in the erythrocyte precursors, leads to premature apoptosis of these cells in the marrow, causing a dip in the number of red blood cells, leading to anemia.
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