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Odontogenic keratocyst

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Author: Sanketh DS, MDS


Odontogenic keratocyst (OKC), is so named because 1) the cyst is odontogenic in origin and 2) the epithelium produces so much keratin, that it accumulates in the cystic lumen. The feature that makes odontogenic keratocyst distinct as compared to other odontogenic cysts, is its biological behaviour! OKCs may exhibit clinically aggressive behaviour, a significant rate of recurrence and association with nevoid basal cell carcinoma syndrome or Gorlin’s syndrome. 


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  1. “Odontogenic keratocyst (OKC) has been reinstated as the preferred term for this simple keratinising cyst.It was decided therefore that odontogenic keratocyst remains the most appropriate name for this lesion, and keratocystic odontogenic tumour (KCOT) was removed from the classification.”

    Reference: Speight, P.M. & Takata, T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch (2017).
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