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Sjogren’s syndrome: Pathogenesis



SJOGREN’S SYNDROME: INTRODUCTION AND PATHOGENESIS

Author: Sanketh DS, MDS

INTRODUCTION

Sjogren’s syndrome (SS) is an autoimmune, chronic inflammatory disease characterized by dense infiltration of lymphocytes in the exocrine glands. Essentially, the body’s own immune cells, the lymphocytes, attack and infiltrate various exocrine glands and cause their functional impairment. The salivary and lacrimal glands are classically affected in SS, resulting in xerostomia (dry mouth) and keratoconjuctivitis sicca (dry eyes) respectively.  Exocrine glands in the gastrointestinal system, respiratory system, skin and vagina may also be affected.

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