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Nanodiagnostics

Nanodiagnostics

Nanodiagnostics, defined as the use of nanotechnology for clinical diagnostic purposes, was developed to meet the demands of clinical diagnostics for increased sensitivity and earlier detection of disease. The use of nanotechnologies for diagnostic applications shows great promise to meet the rigorous demands of the clinical laboratory for sensitivity and cost-effectiveness. New nanodiagnostic tools include quantum dots (QDs), gold nanoparticles, and cantilevers. QDs, which are the most promising nanostructures for diagnostic applications, are semiconductor nanocrystals characterized by high photostability, single-wavelength excitation, and size-tunable emission. QDs and magnetic nanoparticles can be used for barcoding of specific analytes. Gold and magnetic nanoparticles are key components of the bio-barcode assay, which has been proposed as a future alternative to polymerase chain reaction (PCR). The potential diagnostic uses of QDs are numerous, with the most promising applications being in the areas of tumor detection, tissue imaging, intracellular imaging, immunohistochemistry, infectious agent detection, multiplexed diagnostics, and fluoroimmunoassays. Nanodiagnostics promise increased sensitivity, multiplexing capabilities, and reduced cost for many diagnostic applications as well as intracellular imaging.

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Dr Priya


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